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KMID : 0870420010050010169
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2001 Volume.5 No. 1 p.169 ~ p.173
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Clinical Efficacy and Safety of Intravenous levofloxacin in Patients of Abdominal Operati
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Chae Yoon-Seok
Choi Jin-Sub
Lee Jong-Hoon
Kim Kyung-Sik
Lee Woo-Jung
Kim Byong-Ro
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Abstract
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Background/Aims: For the investigation of the efficacy and safety of intravenous levofloxacin, The clinical study was carrried out in 30 patients with abdominal operation, especially in hepatobiliary and pancreatic division.
Methods: Randomly chosen patients received intravenous levofloxacin (250mg bid) for only 7 days. Clinical and microbiological evaluation were conducted on the day of starting and finishing levofloxacin treatmeat except for the case of combined use of antibiotics.
Results: The most commonly isolated organism was staphylococcus aureus(33%, 3/9). The overall bacteriologic eradication rate was 67%, (6/9) with clinical success rate was 96%(29/30), There were no significant dverse effects to stop the administration of the drug.
Conclusion: These results suggest that intravenous levofloxacin is effective and safe antibiotics in the fields management of abdominal operation especially in hepatobiliary and pancreas surgery.
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KEYWORD
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Levofloxacin, Quinolone antibiotics
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